Ovulation Induction Clomiphene Citrate

Clomiphene citrate also known as clomid and serophene is usually given orally for 5 days of a cycle starting with a 50 or 100mg day.

Ovulation induction clomiphene citrate. Ovulation induction medications comprise of oral medications such as clomiphene citrate letrozole and gonadotropins which are in injectable form. The fda has approved this medication for ovulation induction up to 150 mg for 5 days. Usual adult dose for ovulation induction. These medications increase the hormone levels of follicle stimulating hormone fsh and promote the enlargement of the follicles fluid filled sacs carrying the eggs.

Therapy should be initiated on or near the 5th day of the menstrual cycle but may be started at any time in patients without recent uterine bleeding. Approximately 80 of women ovulate while using clomiphene gorlitsky et al. For clomifene the dosage may be increased by 50 mg increments in subsequent cycles until ovulation is achieved. Clomiphene was a revolutionary advance in reproductive medicine and quickly became popular for induction of ovulation because of its ease of administration and minimal side effects.

It constitutes the treatment of choice in hyperandrogenic chronic anovulation. It was first synthesized in 1956 and has been commercially available since 1961. However only 40 of women will achieve pregnancy gysler et al. Clomiphene used in conjunction with a medication called provera may be effective in initiating menstruation and ovulation in women who have no menstrual cycle.

Ovulation induction can be repeated every menstrual cycle. Clomiphene citrate for ovulation induction. Clomiphene citrate has been the most widely used treatment for fertility enhancement for the past 40 years. However at a dosage of 200 mg further increments are unlikely to increase pregnancy chances.

Clomiphene citrate and ovulation induction. Clomiphene citrate clomiphene is the most commonly used drug for ovulation induction since it is inexpensive highly effective and user friendly. By not waiting for medroxyprogesterone acetate induced withdrawal bleeding the time to ovulation is shorter. Treatment begins with a 5 7 day course of provera taken orally.

Sovino h 1 sir petermann t devoto l. 50 mg orally once a day for 5 days. 1 instituto de investigación materno infantil departamento de obstetricia y ginecología unidad de medicina reproductiva campus centro universidad de chile hospital clínico san borja arriarán chile.